Substances Authority for information on how to prevent and detect abuse or diversion of this product. Interactions with other CNS Depressants. Medscape – Detoxification, pain-specific dosing for Methadose, Dolophine opioids; Substantial interpatient variability, see prescribing information for guidance. Find patient medical information for Dolophine Oral on WebMD including its uses , side effects and safety, interactions, pictures, warnings and user ratings.

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In opioid-tolerant patients, convert dolo;hine current total daily dose of all opioids to an oral morphine equivalent dose, then multiply the morphine equivalent dose by the corresponding percentages in the dose conversion table provided in the FDA-approved labeling. Patients tolerant to other opioids may be incompletely tolerant to methadone; use caution when converting patients from other opioids to methadone. Consider the lrescribing of breast-feeding along with the mother’s clinical need for methadone and any potential adverse effects on the breast-fed child from methadone or the underlying maternal condition.

There is considerable individual variation in the rate of taper when discontinuing methadone. In addition, the initiation of longer-acting opioids, such as methadone, is not recommended unless shorter-acting opioids have been unsuccessful, or titration of shorter-acting doses has established a clear daily dose of opioid analgesic that can be provided by using a long-acting form. Patients with acute ulcerative colitis Dollophine or other inflammatory bowel disease may be more sensitive to the constipating effects of opiate prescribong.

Due to the risk of respiratory depression, use methadone with caution in opioid-naive patients. If required, methadone withdrawal is done in decrements of 2 to 2.

Recipient’s Email Separate multiple email address with a comma Please enter valid email address Recipient’s email is required. Women who received methadone maintenance therapy for opioid dependence during pregnancy who are stable may be encouraged to breast-feed, unless another contraindication e.

Do not use as a “prn” or “as needed” analgesic, for acute pain, or if the pain is mild doolophine not expected to persist for an extended period of time.

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Consider these risks jnformation pregnant women treated with methadone for maintenance treatment of opioid addiction. Gradually taper patients off methadone to avoid a withdrawal reaction. Cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of methadone with many types of serotonergic drugs.

Start these patients on lower doses and titrate slowly while carefully monitoring for signs of respiratory and CNS depression. Local tissue reactions may occur with SC use. Methadone may significantly decrease respiratory drive and cause hypoventilation. Detoxification shall not exceed 21 days or be repeated earlier than 4 weeks after completion of a preceding course.


Abrupt discontinuation of methadone in the methadone-maintained patient should be discouraged due to the potential for opioid withdrawal symptoms including lacrimation, rhinorrhea, sneezing, yawning, excessive perspiration, piloerection goose bumpsfever, chills, flushing, restlessness, irritability, weakness, anxiety, depression, dilated pupils, tremors, tachycardia, abdominal cramps, body aches, involuntary twitching and kicking movements, anorexia, nausea, vomiting, diarrhea, intestinal spasms, and weight loss.

It is unclear which, if any, opioids are more likely to cause adrenocortical insufficiency. Decreased respiratory drive and hypoventilation can cause carbon dioxide CO2 retention which can further increase intracranial pressure. Serotonin syndrome may occur within the recommended dosage range.

In patients with pulmonary disease such as chronic obstructive pulmonary disease COPDcor pulmonale, decreased respiratory reserve, hypoxia, hypercapnia, respiratory insufficiency, upper airway obstruction, or preexisting respiratory depression, it is recommended that non-opioid analgesics be considered as alternatives to methadone, as even usual therapeutic doses may decrease respiratory drive and cause apnea in these patient populations.

Because concentrates may numb the mouth or upset the stomach, it may be preferable to mix in 3—4 ounces 90— ml of liquid e. If treatment of informqtion depression in an individual physically dependent on opioids is necessary, administer the opioid antagonist infodmation extreme care; titrate the antagonist dose by using smaller than usual doses. Aspirate prior to injection to avoid injection into a blood vessel. Local tissue reactions may occur with IM use. Asthma, chronic obstructive pulmonary disease COPDcoadministration with other CNS depressants, cor pulmonale, hypoxemia, unformation, pulmonary disease, respiratory depression, respiratory insufficiency, scoliosis, sleep apnea, status asthmaticus.

If adrenocortical insufficiency is suspected, confirm with diagnostic testing as soon as possible. Patients with chronic liver disease may require less frequent dosing intervals. Initially, use a 2: Initial doses may need to be reduced, and doses should be carefully titrated taking into account analgesic effects, adverse reactions, and concomitant drugs that may depress respiration.

Therefore, infants younger than 6 months of age volophine be given opiate agonists but must be closely monitored for apnea for an extended period after their last dose.

Although true opiate agonist hypersensitivity is rare, patients who have demonstrated a prior hypersensitivity reaction should not receive methadone. Divide the total daily methadone dose into an appropriate daily regimen. Methadone is associated with an increased risk for QT prolongation and torsade de pointes TdP.


Although the risk of QT prolongation appears to be dose-relatedwith most incidences of QT prolongation and torsade de pointes occurring in patients receiving large doses for pain management i. In acute situations, patients require close monitoring to avoid excessive toxicity.

Withdrawal of methadone following detoxification treatment. Symptoms of respiratory depression include a reduced urge to breathe, a decreased respiratory rate, or deep breaths separated by long pauses a “sighing” breathing pattern. False positive urine drug screens for methadone have been reported for several drugs including diphenhydramine, doxylamine, clomipramine, chlorpromazine, thioridazine, quetiapine, and verapamil.

Use methadone with caution in patients with adrenal insufficiency i. In addition peescribing slowing the rate of cardiac repolarization thus lengthening the QT interval, methadone may produce cholinergic side effects by stimulating medullary vagal nuclei causing bradycardia and induce the release of histamine causing peripheral vasodilation. Inject subcutaneously taking care not to inject intradermally.

Opioids inhibit the secretion of adrenocorticotropic hormone ACTHcortisol, and luteinizing hormone LH ; however, the thyroid stimulating hormone may be either stimulated or inhibited by opioids.

Health care professionals should not confuse such symptoms with those of opiate abstinence and should not treat anxiety by increasing the dosage of methadone. Patients should seek immediate medical attention if they experience symptoms such as nausea, vomiting, loss of appetite, fatigue, weakness, dizziness, or hypotension. Monitor the neonate for withdrawal symptoms including irritability, hyperactivity, abnormal sleep pattern, high-pitched crying, tremor, vomiting, diarrhea, and failure to gain weight.

Medical withdrawal of methadone maintenance is generally not recommended during pregnancy. Administer dosage every 6 to 8 hours.

Methadone Dolophine, Methadose – Treatment – Hepatitis C Online

Presccribing tablets 3—4 ounces 90— ml of water, orange juice, citrus Tang, citrus flavors of Kool-Aid, or other acidic fruit beverages prior to patient administration.

Methadone treatment for acute or chronic pain management should only be initiated if the potential analgesic or palliative care benefits outweigh the risks. When the patient no longer requires methadone, taper the dose gradually every 2 to 4 days to prevent withdrawal in the physically-dependent patient.

The action of methadone in maintenance treatment is limited to the control of opiate withdrawal symptoms and is not effective in the treatment of anxiety. Avoid use in patients with impaired dilophine or coma.